Inflammation, Not Telomere Length, Predicts Healthy Longevity Of Centenarians
Scientists have discovered the secret why certain people live their life healthy and physically independent over the age of 100.
A team of specialists from Keio University School of Medicine, Tokyo and Newcastle University’s Institute for Ageing, explored which pathological and biological processes are the most important for healthy ageing.
They found that to live that long, over the age of 100, we must keep telomeres long (telomeres are the part of the cells that affect on aging of the cells) and to keep inflammation in the body down.
In groups of semi-super centenarians (people over 105 age), centenarians (from 100-104) and those nearly 100 with their offspring, the experts measured a few of health markers which contribute towards successful ageing, plus blood cell numbers, liver and kidney function, inflammation, telomere length and metabolism.
The experts expected to see an incessant shortening of telomeres as the person is ageing, but they found that the offspring of centenarians, maintained their telomeres, corresponding to 60 years old even when they age 80 or older.
Lower levels of inflammation
The levels of markers for some chronic inflammations increase with age, but at centenarian offspring these levels maintained low, which give them chance for good cognition, independence and long life.
Professor Thomas von Zglinicki, Newcastle University’s Institute for Ageing, in his study, for the first time, explains that inflammation levels can predict successful ageing.
Also, a group of experts from Japan made a research in which were included 1,554 individuals. 684 were centenarians and super centenarians, 536 were very old people, and 167 pairs of offspring and other unrelated family members.
They wanted to identify biological factors that can predict healthy and successful ageing, and to find out if this factor will be recognizable in the offspring of centenarian.
The results suggest that control of chronic inflammation can help people to age slower.
But, very important, the present anti-inflammatories are not right for long-term treatment because of their side-effects.
Professor Nobuyoshi Hirose, from Japanese Semi- Super centenarians Study, and Tokyo Centenarian study says when the experts will find out what makes these people, centenarians and super centenarians different from the other, then it might be possible to improve peoples’ lives as they age.